Proapoptotic role of nuclear clusterin in brain
نویسندگان
چکیده
Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
منابع مشابه
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عنوان ژورنال:
دوره 44 شماره
صفحات -
تاریخ انتشار 2011